The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 70, 53-66, Copyright, 1939, by The Rockefeller Institute for Medical Research New York

ARTICLE

A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : I. SEPARATION OF SOLUBLE ANTIGEN FROM VIRUS



J. E. Smadel M.D.1, R. D. Baird M.D.1, and M. J. Wall 1

1 From the Hospital of The Rockefeller Institute for Medical Research

The virus of lymphocytic choriomeningitis can be sedimented in the ultracentrifuge and washed repeatedly; the virus retains its activity provided that a small amount of normal serum is present in the diluent.

A soluble substance capable of fixing complement in the presence of immune serum can be separated from the virus. Washed virus fixes complement poorly.

The serologically specific soluble antigen is widely distributed in tissues of infected guinea pigs, mice, and monkeys.

 Submitted on April 27, 1939


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