The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 330K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dubos, R. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dubos, R. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 70, 11-17, Copyright, 1939, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : II. PROTECTIVE EFFECT OF THE BACTERICIDAL AGENT AGAINST EXPERIMENTAL PNEUMOCOCCUS INFECTIONS IN MICE



René J. Dubos Ph.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

In the first paper of this series, a description was given of a cell-free extract, obtained from autolysates of a particular strain of a soil bacillus, which selectively inhibits the growth of all the Gram-positive microorganisms so far tested, and exerts on them a bactericidal effect in vitro.

In the present study it is shown that the same agent protects white mice against infection with large numbers of virulent pneumococci. It also exerts a curative effect when administered to mice several hours after injection of the infecting organisms.

The degree of protection afforded, and the minimal effective dose of bactericidal agent, are approximately the same for all virulent pneumococci, irrespective of type specificity.

The bactericidal agent is entirely ineffective against infection with virulent Friediänder bacilli (type B). This agrees with the fact that the agent does not affect Gram-negative bacilli in vitro.

The protective action exerted by the bactericidal agent against experimental pneumococcus infection depends upon the same mechanism which determines its bactericidal effect in vitro.

 Submitted on April 16, 1939


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS