The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 68, 837-852, Copyright, 1938, by The Rockefeller Institute for Medical Research New York

ARTICLE

CELLULAR REACTIONS TO TUBERCULO-PROTEINS COMPARED WITH THE REACTIONS TO TUBERCULO-LIPIDS

Florence R. Sabin M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. Tuberculo-protein in solution induces the formation of monocytes in the normal animal and tubercles of epithelioid cells in that which is tuberculous.

2. Freshly precipitated tuberculo-proteins from the culture media and from the bacilli induce a moderate formation of epithelioid cells in normal animals, and more in the tuberculous.

3. Insoluble forms of tuberculo-protein induce complex tubercular tissue in normal animals. This action is enhanced in the tuberculous.

 Submitted on July 14, 1938


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