The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 68, 641-658, Copyright, 1938, by The Rockefeller Institute for Medical Research New York

ARTICLE

REACTIONS OF NORMAL AND TUBERCULOUS ANIMALS TO TUBERCULO-PROTEIN AND TUBERCULO-PHOSPHATIDE

Kenneth C. Smithburn M.D.1 and Florence R. Sabin M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Prior observations on the cellular reactions to tuberculo-phosphatide are confirmed and compared with reactions induced by this material in tuberculous animals. In the latter the response is accelerated and augmented and simulates the Koch phenomenon.

Tuberculo-protein produces no macroscopic reaction in normal animals. The microscopic reaction of neutrophiles and monocytes regresses in less than a week. The same material in tuberculous animals causes a response characterized by more or less hemorrhage and necrosis, tissue degeneration, and infiltration of neutrophiles and monocytes. Late in the reaction there may be a few epithelioid cells and foreign body giant cells.

Preparations of tuberculo-phosphatide which contain no tubercle bacilli, or only a few, induce the typical cellular response but do not induce hypersensitiveness to tuberculin.

Repeated intradermal skin-test injections of tuberculo-protein MA-100 in normal guinea pigs may be followed by a mild hypersensitiveness to subsequent injections.

 Submitted on June 16, 1938


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