The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 68, 325-334, Copyright, 1938, by The Rockefeller Institute for Medical Research New York

ARTICLE

ALTERED CUTANEOUS CONDITIONS IN THE SKIN OF TUBERCULOUS GUINEA PIGS AS DEMONSTRATED WITH A VITAL DYE

A. L. Joyner M.D.1 and F. R. Sabin M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. In the skin of the tuberculous guinea pig while it is allergic, the spread of a vital dye, pontamine sky blue, and the drainage of the dye into the vascular system take place much more slowly than in the normal animal.

2. In the skin of moribund tuberculous guinea pigs, animals no longer allergic, dye spreads more rapidly than in the normal animal.

3. The spread of dye is somewhat restricted in the skin of guinea pigs infected with a hemolytic Streptococcus. The animals were allergic.

4. The findings suggest that the dye method may disclose altered tissue conditions in the allergic state.

 Submitted on June 2, 1938


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