The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 67, 883-910, Copyright, 1938, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE FATE OF VACCINIA VIRUS ON CULTIVATION IN VITRO WITH KUPFFER CELLS (RETICULO-ENDOTHELIAL CELLS)

Joseph W. Beard M.D.1 and Peyton Rous M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

The pathogenic activity of vaccinia virus is in large part suppressed when it is mixed with living Kupffer cells or clasmatocytes in the test-tube and injected intradermally.

Vaccinia increases in quantity when introduced into cultures of Kupffer cells in vitro, and survives in immediate association with these elements. No antiviral principle is elaborated by them under such conditions.

 Submitted on March 6, 1938


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