The Journal of Experimental Medicine, Vol 66, 565-578,
Copyright, 1937, by The Rockefeller Institute for Medical Research New York
GLOBIN UTILIZATION BY THE ANEMIC DOG TO FORM NEW HEMOGLOBIN
F. S. Robscheit-Robbins Ph.D.1 and
G. H. Whipple M.D.1
1 From the Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, N. Y.
It has been shown that the standard anemic dog can use sheep, goose or dog hemoglobin when given by vein and return quantitatively its equivalent as new dog hemoglobin within the red cells.
Globin at times can be used when given by vein with a quantitative return of new hemoglobin in red cells in these same anemic dogs. Again the administration of globin by vein will inhibit the expected hemoglobin formation; and we believe the toxic effect of the globin is responsible. A digest of globin may be used by the anemic dog to form new hemoglobin. Globin from both horse and dog have been tested and seem to react in identical fashion.
The globin radicle of hemoglobin appears to be an important limiting factor in abundant hemoglobin building in this type of anemia due to blood loss.
Globin fed by mouth is well utilized to form new hemoglobin and we may record a 30 to 40 per cent utilization or a return of 30 to 40 gm. new hemoglobin from the feeding of 100 gm. globin. This is to be compared with the utilization of liver protein—an average return of 13 gm. new hemoglobin for the feeding of 100 gm. liver protein.
Submitted on July 8, 1937
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