The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 66, 413-424, Copyright, 1937, by The Rockefeller Institute for Medical Research New York

ARTICLE

PROPERTIES OF THE TYPE SPECIFIC PROTEINS OF ANTIPNEUMOCOCCUS SERA : I. THE MOUSE PROTECTIVE VALUE OF TYPE I SERA WITH REFERENCE TO THE PRECIPITIN CONTENT



Kenneth Goodner Ph.D.1 and Frank L. Horsfall Jr. M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

The ability to carry out with some measure of precision mouse protection tests for the estimation of potency of antipneumococcus sera has made possible the correlation of the protective potency with the amount of specifically precipitable protein. With antipneumococcus rabbit sera these protective ratios are relatively constant and higher than those with immune horse serum. Type I antipneumococcus horse sera, on the other hand, show no such constancy but fall into two groups; and there is as yet no simple method for determining to which group a serum belongs.

Submitted on June 22, 1937


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