The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 65, 557-564, Copyright, 1937, by The Rockefeller Institute for Medical Research New York

ARTICLE

EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : IV. PREVENTION OF THE INJURIOUS EFFECTS OF NEPHROTOXIN IN VIVO BY KIDNEY EXTRACT



Homer F. Swift M.D.1 and Joseph E. Smadel M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

A saline extract of perfused rat kidney administered intravenously to rats immediately before injecting an anti-rat-kidney serum, by the same route, prevents renal damage. A preliminary injection of physiological salt solution or of an extract of perfused rat liver has no preventive effect.

These findings are a further indication that the nephrotoxic effect induced by anti-kidney serum is dependent upon a relatively organ specific antibody, nephrotoxin.

 Submitted on January 18, 1937


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