The Journal of Experimental Medicine
Symposium on Dendritic Cells
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The Journal of Experimental Medicine, Vol 63, 179-184, Copyright, 1936, by The Rockefeller Institute for Medical Research New York

ARTICLE

A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : III. INTERPRETATION OF FINDINGS



C. H. Andrewes M.D.1 and R. E. Shope M.D.1

1 From the National Institute for Medical Research, Hampstead, London, and the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

A strain of rabbit fibroma virus (changed virus) producing partly fibromatous, partly inflammatory, lesions is believed to represent a mixture of the original virus with a strain (inflammatory virus) causing only necrotic and inflammatory lesions. The inflammatory virus does not represent a contamination from without, but probably arose as a mutant from the original strain. The occurrence of mutation amongst viruses and the propriety of using the word in this field are briefly discussed. Consideration is also given to the nature of the change in the virus which leads to a tissue reaction so widely different from that produced by the original strain.

Submitted on October 22, 1935


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