The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 63, 59-68, Copyright, 1936, by The Rockefeller Institute for Medical Research New York

ARTICLE

INHIBITION OF THE SHWARTZMAN PHENOMENON

Tomio Ogata M.D.1

1 From the Laboratories of The Mount Sinai Hospital, New York, and the Serochemical Institute of the Tokyo Imperial University Medical School, Tokyo, Japan

The Shwartzman phenomenon can be inhibited by an intravenous injection of a potent bacterial filtrate within a few hours before or after the preparatory intradermal injection.

The inhibitory effect is produced non-specifically by filtrates potent in the elicitation of the Shwartzman phenomenon, and it is of a transitory nature.

The relation of the observation described to anaphylactic desensitization and to its clinical significance is discussed in this paper.

 Submitted on October 13, 1935


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