ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS

doi:10.1084/jem.61.5.689

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The Journal of Experimental Medicine, Vol 61, 689-702, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS

Thomas M. Rivers M.D.¹ and Francis F. Schwentker M.D.¹

¹ From the Hospital of The Rockefeller Institute for Medical Research

The repeated intramuscular injections of aqueous emulsionsand alcohol-ether extracts of sterile normal rabbit brains insome manner produced pathological changes accompanied by myelindestruction in the brains of 7 of 8 monkeys (Macacus rhesus).Eight, control monkeys remained well. Cultures from the involvedbrains remained sterile, and no transmissible agent was demonstratedby means of intracerebral inoculations of emulsions of bitsof the brains into monkeys, rabbits, guinea pigs, and whitemice.

Submitted on January 30, 1935

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