The Journal of Experimental Medicine, Vol 61, 351-359,
Copyright, 1935, by The Rockefeller Institute for Medical Research New York
STUDIES ON AN UNCOMPLICATED CORYZA OF THE DOMESTIC FOWL
:
III. THE EFFECT OF EXTRANASAL INJECTION ON THE GROWTH OF THE FOWL CORYZA BACILLUS
John B. Nelson Ph.D.1
1 From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The mucous surfaces of the nasal passages and orbital sinuses appear to afford particularly favorable conditions for the development of the fowl coryza bacillus. Injected in the nasal tract, in any appreciable number, the bacilli regularly develop and may continue to exist for a considerable period of time in spite of an active inflammatory reaction on the part of the host.
The specific bacillus multiplies either sparsely or not at all when injected extranasally, regardless of the nature of the cellular surface with which it is brought in contact.
If the locus of injection is in communication with the upper air passages, as in the case of the trachea, internal ear, and orbital cavity, the bacilli may be carried there, even in the absence of a local development, and produce a coryza.
Introduction of the bacilli in loci not in communication with the upper air passages is followed by a nasal carriage only in the case of the peritoneal cavity. Following intraperitoneal injection, 7 of 12 birds showed the specific bacillus in the nasal passages and except in one instance without an accompanying inflammation.
Submitted on December 11, 1934
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