The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 61, 173-182, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EXPERIMENTAL PRODUCTION IN DOGS OF ACUTE STOMATITIS, ASSOCIATED WITH LEUCOPENIA AND A MATURATION DEFECT OF THE MYELOID ELEMENTS OF THE BONE MARROW

D. K. Miller M.D.1 and C. P. Rhoads M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

An ulcerative stomatitis associated with leucopenia and granulopenia can be induced in dogs by means of a diet causing black tongue. The decrease of circulating leucocytes is due to a suppression of maturation of the erythropoietic elements of the bone marrow. The changes as a whole have a resemblance to those occurring in human beings with acute agranulocytosis.

Submitted on September 9, 1934


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