The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 61, 9-15, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

CORTIN PROTECTION AGAINST ANAPHYLACTIC SHOCK IN GUINEA PIGS

J. Wolfram 1 and R. L. Zwemer Ph.D.1

1 From the Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York

Studies have been made on a possible protective action of cortin in the prevention of anaphylactic shock induced by crystallized egg albumin.

Of sixteen control guinea pigs only two survived.

Sixteen of thirty-three cortin-treated animals received hormone at the optimum period of from 2 to 6 hours before the shocking dose. Nine survived and two others showed some protection. In groups treated at other time intervals the evidence of protection is inconclusive.

2 weeks after the first test the cortin-treated survivors succumbed to a second antigen dose, which was not preceded by cortical extract.

 Submitted on October 12, 1934


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