The Journal of Experimental Medicine
BioSymposia
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The Journal of Experimental Medicine, Vol 60, 773-791, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE PROBLEM OF THE SIGNIFICANCE OF THE INCLUSION BODIES FOUND IN THE SALIVARY GLANDS OF INFANTS, AND THE OCCURRENCE OF INCLUSION BODIES IN THE SUBMAXILLARY GLANDS OF HAMSTERS, WHITE MICE, AND WILD RATS (PEIPING)

Ann G. Kuttner M.D.1 and Shao-Hsun Wang M.D.1

1 From the Department of Medicine, Peiping Union Medical College, Peiping, China

1. Acidophilic intranuclear inclusion bodies occur in the salivary glands of Chinese infants dying from miscellaneous causes. The lesion is similar to that previously described in infants in Europe and America.

2. Attempts to prove that this lesion is due to an infectious agent by its production in animals have been unsuccessful.

3. Acidophilic intranuclear inclusion bodies have been found in the submaxillary glands of hamsters, white mice, and wild rats.

4. Evidence is presented to show that the lesion in hamsters, white mice, and wild rats is due to a virus, which is specific for each species, being transmissible to normal individuals of this breed, and which is very similar to the submaxillary gland virus of guinea pigs.

 Submitted on September 23, 1934


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