The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 59, 543-552, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

FAILURE TO NEUTRALIZE THE POLIOMYELITIS VIRUS WITH SERA OF ADULT MACACUS RHESUS AND OF YOUNG FEMALE RHESUS TREATED WITH ANTERIOR PITUITARY EXTRACTS

N. Paul Hudson M.D.1, Edwin H. Lennette 1, and Ernest Q. King M.D.1

1 From the Department of Hygiene and Bacteriology and the Department of Medicine of the Division of Biological Sciences, The University of Chicago, Chicago

1. Twelve specimens of serum from nine adult male monkeys failed to neutralize the virus of poliomyelitis.

2. Ten samples of serum obtained from three adult female monkeys at various phases of the menstrual cycle likewise proved incapable of neutralizing the virus. An eleventh serum, drawn from a fourth female 32 days postpartum, gave irregular results. It neutralized once and failed to do so on second test. This is the only suggestion in our experiments that a physiological factor may play a part in poliomyelitis immunity.

3. Fourteen sera from ten immature monkeys caused to menstruate by treatment with anterior pituitary extract were devoid of virucidal property. This treatment failed also to induce a systemic resistance to intracerebral injections of virus in the nine monkeys of the same group available for test.

4. We were unable to demonstrate in our monkeys a correlation between virucidal capacity of the serum and maturity or physiological variations as exemplified by menstruation.

 Submitted on January 17, 1934


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