The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 59, 83-95, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE TOXIC PROPERTIES OF SERUM EXTRACTS OF HEMOLYTIC STREPTOCOCCI

Julia T. Weld 1

1 From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York

1. A method is described whereby toxic substances may be extracted from hemolytic streptococci with inactivated serum.

2. Such extracts contain large amounts of hemotoxin and leucocidin.

3. Their intravenous injection into mice causes marked hemoglobinuria, anemia, and death.

4. There is evidence that this anemia is not the only cause of death of these animals.

5. Incomplete work seems to indicate that the hemotoxin and the lethal poisons are not antigenic.

6. Certain biological properties of the extract are described.

 Submitted on September 28, 1933


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