INFECTIOUS PAPILLOMATOSIS OF RABBITS: WITH A NOTE ON THE HISTOPATHOLOGY

doi:10.1084/jem.58.5.607

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The Journal of Experimental Medicine, Vol 58, 607-624, Copyright, 1933, by The Rockefeller Institute for Medical Research New York

ARTICLE

INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY

Richard E. Shope M.D.¹ and E. Weston Hurst M.D.¹

¹ From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

A papilloma has been observed in wild cottontail rabbits andhas been found to be transmissible to both wild and domesticrabbits. The clinical and pathological pictures of the conditionhave been described. It has been found that the causative agentis readily filtrable through Berkefeld but not regularly throughSeitz filters, that it stores well in glycerol, that it is stillactive after heating to 67°C. for 30 minutes, but not afterheating to 70°C., and that it exhibits a marked tropismfor cutaneous epithelium. The activities and properties of thepapilloma-producing agent warrant its classification as a filtrablevirus.

Rabbits carrying experimentally produced papillomataare partially or completely immune to reinfection and, furthermore,their sera partially or completely neutralize the causativevirus. The disease is transmissible in series through wild rabbitsand virus of wild rabbit origin is readily transmissible todomestic rabbits, producing in this species papillomata identicalin appearance with those found in wild rabbits. However, thecondition is not transmissible in series through domestic rabbits.The possible significance of this observation has been discussed.The virus of infectious papillomatosis is not related immunologicallyto either the virus of infectious fibroma or to that of infectiousmyxoma of rabbits.

Submitted on July 18, 1933

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