The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 58, 329-339, Copyright, 1933, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RESISTANCE OF RABBITS TO TUBERCULOSIS AFTER VACCINATION WITH PARTIALLY DEFATTED TUBERCLE BACILLI

Kenneth C. Smithburn M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. A vaccine prepared from partially defatted bovine tubercle bacilli influenced favorably the survival time after inoculation with living virulent bovine tubercle bacilli.

2. Accompanying this increased resistance was a sustained lymphocytosis in the vaccinated animals.

3. The vaccine induced a transitory anemia and leucopenia.

4. A similar preparation of partially defatted human tubercle bacilli possessed the power to sensitize guinea pigs to tuberculo-protein.

 Submitted on June 14, 1933


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