The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 58, 153-160, Copyright, 1933, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EFFECT OF PNEUMOCOCCUS AUTOLYSATES UPON PNEUMOCOCCUS DERMAL INFECTION IN THE RABBIT

Kenneth Goodner Ph.D.1

1 From the Hospital of The Rockefeller Institite for Medical Research

In pneumococcus dermal infections in rabbits, the addition of pneumococcus autolysate to an infective inoculum favors the invasiveness of the particular strain employed, but does not alter the kind of virulence possessed by that strain.

Autolysates exhibiting this enhancing property also induce purpura in mice and inhibit the coagulation of rabbit blood. The relation of these properties to the infectivity of Pneumococcus and the possible role of bacterial autolysis in natural infection are discussed.

 Submitted on March 13, 1933


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