The Journal of Experimental Medicine
Randox
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carpenter, C. M.
Right arrow Articles by Warren, S. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Carpenter, C. M.
Right arrow Articles by Warren, S. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 56, 751-762, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE PHYSIOLOGICAL EFFECTS OF FEVER TEMPERATURES : IV. THE HEALING OF EXPERIMENTAL SYPHILIS LESIONS IN RABBITS BY SHORT WAVE FEVERS



Charles M. Carpenter Ph.D.1, Ruth A. Boak Ph.D.1, and Stafford L. Warren M.D.1

1 From the Department of Medicine, Division of Radiology of the University of Rochester, School of Medicine and Dentistry, Rochester, N. Y.

1. Multiple, unsustained fevers (41–42°C.) produced by irradiation in a high frequency electrostatic field (10,000 kilocycles) destroyed T. pallidum in rabbits with active syphilitic lesions as determined by the injection into normal rabbits of extracts prepared from their testes and popliteal lymph nodes.

2. One febrile period of 6 hours at a temperature of 41.5–42°C. was likewise found to be sufficient to destroy T. pallidum.

3. Infection with T. pallidum persisted in a control series of untreated rabbits for as long as 395 days after inoculation, but clinical healing occurred in from 3 to 4 months after injection.

4. The time interval between inoculation and fever treatment, or between the end of the fever treatment and reinoculation, did not affect the results.

5. The fever treatment was effective at any stage of experimental syphilis in rabbits.

 Submitted on June 29, 1932


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS