The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 56, 587-600, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES



Herbert M. Klein M.D.1

1 From the Laboratories of The Mount Sinai Hospital, New York

Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity.

A similar modification occurs spontaneously in meningococcus culture filtrates on standing.

Inasmuch as these changes parallel those occurring in the conversion of diphtheria toxin into toxoid, it is justifiable to consider such altered meningococcus toxin as meningococcus toxoid.

 Submitted on June 17, 1932


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