The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 56, 521-530, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE QUANTITATIVE ACTION OF A SPECIFIC ENZYME IN TYPE III PNEUMOCOCCUS DERMAL INFECTION IN RABBITS

Kenneth Goodner Ph.D.1 and René Dubos Ph.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

The enzyme which specifically decomposes the capsular polysaccharide of Type III Pneumococcus must be used in certain definite amounts in order to bring about the recovery of rabbits infected intradermally with this organism. The experiments reported in this paper indicate that the minimal amounts of enzyme required bear a definite relationship to the severity of the infection as gauged by the number of pneumococci present in the circulating blood.

Submitted on June 2, 1932


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