The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 56, 483-492, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR : VI. ACTION OF THE ASSOCIATED INHIBITOR ON MOUSE TUMORS



James B. Murphy M.D.1 and Ernest Sturm 1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Water extracts of desiccates of certain relatively slow-growing strains of Chicken Tumors I and X, or the exudates from such tumors, definitely inhibited the growth of a mouse sarcoma (Crocker 180), and were without effect on a mouse carcinoma (Bashford 63) or Mouse Tumor S/37, a rapidly growing sarcoma derived from the stroma of a carcinoma. Extensive control tests with extracts from rapidly growing chicken tumors, and from tissues of normal and immune chickens showed no inhibiting action. There was no demonstrable action on the mouse tumors of sera from immunized rabbits, which neutralize the chicken tumor agent, nor of the sera from chickens highly immune to the chicken tumors.

Submitted on June 13, 1932


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