The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 55, 761-767, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VI. THE SYNTHESIS OF p-AMINOPHENOL alpha-GLUCOSIDE AND ITS COUPLING WITH PROTEIN



Walther F. Goebel Ph.D.1, Frank H. Babers 1, and Oswald T. Avery M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

1. The synthesis of p-aminophenol alpha-glucoside has been described. This glucoside can be coupled to any protein to yield a synthetic alpha-glucoside-protein complex.

2. A synthetic ß-glucoside-protein complex has also been prepared.

3. These synthetic sugar-protein complexes have been used as immunizing antigens in order to ascertain whether alpha- and ß-glucosidic unions influence the specificity of the immune response in animals. The results of the immunological studies are presented in the following paper.

 Submitted on February 23, 1932


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