The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 55, 455-463, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EFFECT OF TESTICLE EXTRACT ON THE GROWTH OF TRANSPLANTABLE MOUSE TUMORS

Radford C. Tanzer M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Grafts of a transplantable mouse sarcoma designated as No. 180, and those of an attenuated strain of a more malignant Sarcoma S/37, treated with testicle extract, either fail to grow on inoculation or result in tumors of a lower growth rate than the controls. Autografts of spontaneous mouse tumors so treated show little if any effect, while the Bashford adenocarcinoma and the unattenuated S/37 are unaffected. The factor in testicle extract responsible for the retarding activity passes readily through a Berkefeld filter and is thermostable.

Submitted on November 2, 1931


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