The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 55, 393-404, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE ACTION OF A SPECIFIC ENZYME UPON THE DERMAL INFECTION OF RABBITS WITH TYPE III PNEUMOCOCCUS

Kenneth Goodner Ph.D1, René Dubos Ph.D.1, and Oswald T. Avery M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

The action of the enzyme which specifically decomposes the capsular polysaccharide of Type III Pneumococcus has been tested in Type III pneumococcus dermal infections in rabbits. When injected in sufficient amounts, this enzyme is capable of bringing about a favorable and early termination of the experimental disease which ordinarily is fatal in nearly all instances.

The results of the present study yield further evidence that the capsular substance is of great importance in pneumococcus infection, since, in so far as known, the only action of which the specific enzyme is capable is that of decomposing the capsular polysaccharide.

 Submitted on December 9, 1931


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