The Journal of Experimental Medicine
3rd Skeletal Biology and Medicine Symposium
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The Journal of Experimental Medicine, Vol 55, 91-99, Copyright, 1932, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE TRANSFORMATION IN VITRO OF R PNEUMOCOCCI INTO S FORMS OF DIFFERENT SPECIFIC TYPES BY THE USE OF FILTERED PNEUMOCOCCUS EXTRACTS

J. Lionel Alloway M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

1. Avirulent R pneumococci derived from S forms of a specific type may be changed by growth in broth containing anti-R serum and a heated, filtered extract of S pneumococci of a different type, into virulent S organisms identical in type with the bacteria extracted. This has been accomplished in the case of R strains derived from Type II pneumococci, employing extracts prepared from Type III and Type I S forms.

2. The constituents of the extract supply an activating stimulus of a specific nature in that the R pneumococci acquire the capacity of elaborating the capsular material peculiar to the organisms extracted.

 Submitted on October 16, 1931


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