CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS: V. THE IMMUNOLOGICAL SPECIFITY OF AN ANTIGEN PREPARED BY COMBINING THE CAPSULAR POLYSACCHARIDE OF TYPE III PNEUMOCOCCUS WITH FOREIGN PROTEIN

doi:10.1084/jem.54.3.437

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The Journal of Experimental Medicine, Vol 54, 437-447, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : V. THE IMMUNOLOGICAL SPECIFITY OF AN ANTIGEN PREPARED BY COMBINING THE CAPSULAR POLYSACCHARIDE OF TYPE III PNEUMOCOCCUS WITH FOREIGN PROTEIN

Oswald T. Avery M.D.¹ and Walther F. Goebel Ph.D.¹

¹ From the Hospital of The Rockefeller Institute for Medical Research

1. Type-specific antipneumococcus immunity has been inducedin rabbits by immunization with antigen prepared by combininga specific derivative of the capsular polysaccharide of TypeIII Pneumococcus with globulin from horse serum.

2. Rabbitsimmunized with this antigen acquire active immunity againstinfection with virulent Type III pneumococci.

3. The sera ofthe immune rabbits contain type-specific antibodies which precipitatethe Type III capsular polysaccharide, agglutinate Type III pneumococci,and specifically protect mice against Type III infection.

4.The experimental data are discussed with reference to: (1) theconcurrence in the immune sera of type-specific antibodies forPneumococcus and precipitins for horse globulin; (2) the determininginfluence of the capsular polysaccharide on the specificityof the antigen as a whole; (3) the unity of the type-specificprecipitins, agglutinins, and protective antibodies inducedby a single component of the pneumococcus in chemical unionwith an unrelated, animal protein.

Submitted on June 1, 1931

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