The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 54, 431-436, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IV. THE SYNTHESIS OF THE p-AMINOBENZYL ETHER OF THE SOLUBLE SPECIFIC SUBSTANCE OF TYPE III PNEUMOCOCCUS AND ITS COUPLING WITH PROTEIN



Walther F. Goebel Ph.D.1 and Oswald T. Avery M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

1. The p-amino and p-nitromonobenzyl ethers of the specific polysaccharide of Type III Pneumococcus have been prepared.

2. The diazonium ether of the specific polysaccharide has been coupled with serum globulin to yield a specific polysaccharide-protein complex and this complex has been used for immunization. The results of the immunological studies are presented in the following paper.

 Submitted on June 1, 1931


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