The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 53, 399-404, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMMUNIZATION WITH MIXTURES OF POLIOMYELITIS VIRUS AND ALUMINUM HYDROXIDE

C. P. Rhoads M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Preliminary experiments are presented which indicate that poliomyelitis virus can be inactivated by a certain preparation of aluminum hydroxide. This effect is seen at neutrality and at a pH of 5.5, but not at a pH of 8.8. Monkeys treated by repeated subcutaneous injections of poliomyelitis virus so inactivated evince immunity as shown by resistance to intranasal instillation and intracerebral inoculation as well as by the neutralizing power of their sera. The treatments which give rise to the immunity produce no symptoms of disease.

Submitted on November 30, 1930


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