The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 53, 219-242, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE GRADIENT OF VASCULAR PERMEABILITY : III. THE GRADIENT ALONG THE CAPILLARIES AND VENULES OF FROG SKIN



Peyton Rous M.D.1 and Frederick Smith M.B., B.Ch.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

A steeply mounting gradient of permeability is demonstrable along the meshwork of capillaries which connects the arterioles and venules of the skin of the frog. The venules incorporated in the meshwork are even more permeable than the capillary meshes giving into them.

The presence of the gradient under such differing conditions as exist along frog and mammalian capillaries enables one to rule out certain factors which might be invoked to explain it; and it is not explainable in terms of those influences generally recognized as conditioning exchange between the blood and tissues. Not improbably it results from a structural differentiation along the capillary.

 Submitted on October 31, 1930


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