The Journal of Experimental Medicine
Accuri Cytometers
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The Journal of Experimental Medicine, Vol 53, 185-193, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMMUNIZATION AGAINST VACCINIA BY NON-INFECTIVE MIXTURES OF VIRUS AND IMMUNE SERUM

C. P. Rhoads M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. Vaccine virus and specific immune serum mixed in such proportions as to produce no lesion when inoculated intradermally induce immunity when instilled into the nasal cavities of rabbits.

2. The mixture is also effective when inoculated subcutaneously.

3. Immunity is brought about with a minimum of systemic reaction and no local one.

4. When the mixtures are incompletely neutralized generalized vaccinia results.

 Submitted on October 13, 1930


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