The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 53, 179-183, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON INFLAMMATION : VI. FIXATION OF TRYPAN BLUE IN INFLAMED AREAS OF FROGS



Valy Menkin M.D.1

1 From The Henry Phipps Institute, University of Pennsylvania, Philadelphia, the Marine Biological Laboratory, Woods Hole, and the Department of Pathology, Harvard Medical School, Boston

Trypan blue injected into the circulating blood stream of frogs accumulates rapidly in an inflamed area.

When trypan blue is injected directly into the area of inflammation it is fixed in situ and fails to diffuse outward.

If the dye is injected at the periphery of an inflamed area it fails to enter the site of inflammation. This failure of penetration is caused by the occlusion of lymphatic vessels and the presence of a network of fibrin in the inflamed area.

These experiments furnish additional evidence that fixation of foreign substances by the inflammatory reaction is due to mechanical obstruction caused by a network of fibrin and by thrombosed lymphatics at the site of inflammation.

 Submitted on October 30, 1930


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