The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 53, 137-142, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

REINFORCEMENT OF CONVALESCENT ANTIPOLIOMYELITIC SERUM IN THE MONKEY

C. P. Rhoads M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

A comparison has been made of the neutralizing value of pooled convalescent monkey serum for the filtered virus of poliomyelitis, before and after a series of reinforcement injections of the same virus strain.

The strength of the pooled convalescent serum is increased by the reinforcing procedure.

The original monkey convalescent serum had a neutralization value much below that of a pooled human convalescent serum. By reinforcement the neutralization value of the monkey serum was brought approximately to that of the human serum.

One sample of serum from a supposedly normal child of 8 years exhibited a neutralizing value approximately equal to that of a pooled human convalescent serum and the reinforced pooled monkey serum.

 Submitted on September 30, 1930


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