The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 52, 865-871, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

FURTHER EXPERIMENTS IN TYPHUS FEVER : IV. INFECTION WITH WASHED MEXICAN RICKETTSIAE AND IMMUNITY TO EUROPEAN TYPHUS



Hans Zinsser M.D.1 and M. Ruiz Castaneda M.D.1

1 From the Department of Bacteriology and Immunology, Harvard University Medical School, Boston

Precise interpretation of our experiments seems to impose the following conclusions:

Guinea pigs inoculated with washed Rickettsiae from Mexican typhus fever develop a disease identical with that resulting from inoculations with whole tunica scrapings, blood or other virulent material, and become thereby immunized to European typhus fever.

The etiological agent of Mexican typhus fever is the Rickettsia body of the type described by Mooser (5) in the tunica vaginalis of infected guinea pigs; and it is likely that the etiological agent of European typhus fever is an organism similar to this, but not identical with it in some of its minor biological characteristics.

 Submitted on August 17, 1930


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