The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 52, 457-464, Copyright, 1930, by The Rockefeller Institute for Medical Research New York


ARTICLE

IMMUNITY TO POLIOMYELITIS IN MOTHERS AND THE NEWBORN AS SHOWN BY THE NEUTRALIZATION TEST

W. Lloyd Aycock M.D.1 and S. D. Kramer M.D.1

1 From the Department of Preventive Medicine and Hygiene, Harvard Medical School, Boston, and the Research Laboratory of the Vermont Department of Public Health, Burlington

Neutralization tests for the virus of poliomyelitis on blood serum of urban mothers and their newborn infants showed that immunity was present in ten out of twelve (83 per cent) infants and in ten out of twelve (83 per cent) mothers, with a complete correspondence between mother and infant. These tests point to passive transmission of immunity from mother to infant. Previous tests on other children (1 to 5 years) indicate that immunity in infants is transitory. Previous observations concerning the extent of immunity in urban adults are confirmed and extended. The results of these tests are in accord with the age distribution of poliomyelitis and parallel corresponding observations in diphtheria.

Submitted on June 9, 1930


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