The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 52, 235-252, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

A TYPE SPECIFIC SUBSTANCE DISTINCT FROM THE SPECIFIC CARBOHYDRATE IN PNEUMOCOCCUS TYPE I

John F. Enders Ph.D.1

1 From the Department of Bacteriology and Immunology, Harvard University Medical School, Boston

1. Evidence has been presented for the existence of a substance distinct from the specific carbohydrate in the autolytic products of Pneumococcus Type I.

2. The substance reacts specifically by precipitating homologous antiserum which either occurs naturally without antibody against the specific carbohydrate or has been deprived of that antibody artificially.

3. In guinea pigs passively sensitized with such antisera the homologous autolysate containing the substance alone produces typical lethal anaphylactic shock.

4. In weakly alkaline solution the substance is destroyed by boiling. In weakly acid solution it resists a temperature of 100°C. for at least frac12 hour. Autoclaving for 1 hour at 15 pounds pressure in either acid or alkaline solution destroys its activity as precipitinogen.

5. The substance is resistant to peptic digestion.

6. The chemical nature and the possible identification of the substance as a haptene have been discussed.

 Submitted on May 11, 1930


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