OBSERVATIONS ON THE PHAGOCYTOSIS OF THE PNEUMOCOCCUS BY HUMAN WHOLE BLOOD: I. THE NORMAL PHAGOCYTIC TITRE, AND THE ANTI-PHAGOCYTIC EFFECT OF THE SPECIFIC SOLUBLE SUBSTANCE

doi:10.1084/jem.51.5.675

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The Journal of Experimental Medicine, Vol 51, 675-684, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

OBSERVATIONS ON THE PHAGOCYTOSIS OF THE PNEUMOCOCCUS BY HUMAN WHOLE BLOOD : I. THE NORMAL PHAGOCYTIC TITRE, AND THE ANTI-PHAGOCYTIC EFFECT OF THE SPECIFIC SOLUBLE SUBSTANCE

Hugh K. Ward M.B.¹

¹ From the Department of Bacteriology and Immunology of the Harvard University Medical School, Boston

1. The phagocytic titre of whole human blood against the threetypes of pneumococcus was determined in a number of individuals.The titre varied over a considerable range in different subjects.

2.Contrary to expectation, the titre in early cases of untreatedpneumonia was quite high against the infecting organism, pointingto a local rather than a general lowering of resistance in infectionwith this organism.

3. Sia's work was confirmed, that the specificcarbohydrate has a specific anti-phagocytic action on the blood.This action is more marked in the case of Type III than in TypeI.

Submitted on January 23, 1930

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