The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 51, 483-492, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE IMMUNOLOGICAL SIGNIFICANCE OF COLOSTRUM : II. THE INITIAL FEEDING OF SERUM FROM NORMAL COWS AND COWS IMMUNIZED TOWARDS B. COLI IN PLACE OF COLOSTRUM



Theobald Smith M.D.1 and Ralph B. Little V.M.D.1

1 From the Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

Under certain safeguards, such as isolation, calves from a large dairy herd have been raised by feeding normal and immune cow serum in place of colostrum. The losses were about one out of ten in the later experiments. This outcome may probably be improved by the subcutaneous injection of serum during the first day. This loss may be no greater than that under ordinary conditions, since sporadic deaths among calves are not infrequent. However, no satisfactory statistics are available for comparison with results as given above.

Submitted on January 5, 1930


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