The Journal of Experimental Medicine, Vol 51, 463-472,
Copyright, 1930, by The Rockefeller Institute for Medical Research New York
REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS
:
III. REACTIONS AT THE SITE OF INJECTION
Louis A. Julianelle Ph.D.1
1 From the Hospital of The Rockefeller Institute for Medical Research
1. Following repeated intracutaneous injections of heat-killed pneumococci rabbits acquire an increased skin reactivity.
2. The increased skin reactivity reaches a maximum after 4 to 6 injections have been made, after which it becomes greatly diminished.
3. The relationship of increased skin reactivity to active resistance to infection by Pneumococcus, and to the presence of species-specific antibodies in the blood, is still obscure.
4. The increased skin reactivity is not transferable by serum from a highly reactive to a normal rabbit.
5. After regression of the reaction to the first injection of Pneumococcus into the skin, there frequently follows a recrudescence, or exacerbation, of the reaction.
6. The increased skin reactivity and secondary reactions are incited alike by all types and all forms of Pneumococcus.
Submitted on December 30, 1929
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