The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 49, 681-694, Copyright, 1929, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE REACTION OF HUMAN BILE AND ITS RELATION TO GALL STONE FORMATION

John G. Reinhold 1 and L. Kraaer Ferguson M.D.1

1 From the Biochemical Laboratory of the Philadelphia General Hospital, the Biochemical Department of the Graduate School of Medicine, and the Department of Surgery (Division C), University of Pennsylvania, Philadelphia.

1. The human gall bladder acidifies the bile. In this respect its action is similar to that of the gall bladders of lower animals, previously described by other workers.

2. The hydrogen ion concentration of gall bladder bile is increased considerably in cases of obstruction of the common or cystic ducts. The highest values were found following complete obstruction.

3. The occurrence of gall stones was not associated with a consistent change in the hydrogen ion concentration of the gall bladder bile.

 Submitted on December 27, 1928


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