The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 42, 727-745, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : THIRD PAPER.



Michael Heidelberger Ph.D.1, Walther F. Goebel Ph.D.1, and Oswald T. Avery M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research.

1. Refinements in the methods for the isolation of the soluble specific substances of Types II and III pneumococcus are described.

These improvements have resulted in the isolation of the end-products in a form free from nitrogen and of enhanced activity with immune serum.

2. The soluble specific substance of Type I pneumococcus is described and shown to differ sharply from the corresponding substances of the other two types, each of which, in turn, differs from the other.

3. Progress is reported on the identification of the sugar units from which the polysaccharides are built up.

4. The evidence so far accumulated is believed to favor strongly the view that the polysaccharides isolated are the actual specific substances of Pneumococcus.

 Submitted on June 29, 1925


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