The Journal of Experimental Medicine
Accuri Cytometers
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marmorston-Gottesman, J.
Right arrow Articles by Jaffe, H. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Marmorston-Gottesman, J.
Right arrow Articles by Jaffe, H. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 42, 413-418, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

COMPENSATORY HYPERTROPHY OF THE THYMUS GLAND IN THE RAT

J. Marmorston-Gottesman M.D.1 and Henry L. Jaffe M.D.1

1 From the Division of Laboratories of Montefiore Hospital and the Hospital for Joint Diseases, New York.

Previous experimental work concerning enlargement of the thymus has dealt mainly with the regeneration which follows partial or subtotal removal, or with the regeneration which follows transplantation. We planned our experiments to obtain evidence of uncomplicated hypertrophy by removing one lobe and studying the enlargement of the remaining lobe. Our results clearly indicate that such hypertrophy takes place in young animals. They emphasize the functional importance of this gland before puberty, since the compensatory enlargement does not take place after puberty. The results further indicate that with the onset of involution there is a marked or almost total decline in the function of the gland, in spite of the fact that anatomically the thymus may persist to old age. With the appearance of a stimulus for regeneration, as, for instance, suprarenalectomy, the involuted gland takes on functional activity.

Submitted on June 2, 1925


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS