The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 42, 201-213, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE FUNCTION OF MACROPHAGES IN LOCAL RESISTANCE TO BACTERIAL INFECTIONS

Waro Nakahara D.M.Sc.1

1 From the Laboratories of The Rockefeller Institute for Medical Research.

Coincident with the marked macrophage reaction induced in the peritoneal cavity by oil injection, there is an increased resistance of this location to bacterial infections. Animals so prepared dispose of Bacillus coli in a much shorter time than normal animals, and survive multiples of the fatal doses of staphylococci and pneumococi.

The amount of oil injected is in itself incapable of inhibiting bacterial growth, nor is cell-free exudate from an oil-injected animal potent in this regard. The macrophages in the exudate, on the other hand, actively phagocytize bacteria. These facts lead to the conclusion that the increased resistance is due primarily to the action of macrophages.

 Submitted on May 13, 1925


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