The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 42, 155-161, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

EFFECT OF PREPUBERTY CASTRATION ON SUBSEQUENT CANCER IMPLANTATION

James B. Murphy M.D.1 and Ernest Sturm 1

1 From the Laboratories of The Rockefeller Institute for Medical Research.

Male and female mice castrated during the first 7 weeks of life and implanted with cancer at later periods show a resistance definitely higher than do intact animals of the same age. This increased refractiveness is evident at 3 months after the operation but is more pronounced at 8 months to a year. Even castration in early adult life seems to increase the refractory state to later cancer inoculation. On the other hand, adult mice inoculated within a week after castration show slight if any evidence of increased resistance.

Submitted on May 20, 1925


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