The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 41, 487-502, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES IN EXPERIMENTAL SYPHILIS : II. THE INFLUENCE OF A NON-SPECIFIC INFLAMMATORY REACTION UPON THE DEVELOPMENT OF THE CHANCRE.



Alan M. Chesney M.D.1 and Jarold E. Kemp M.D.1

1 From the Department of Medicine of the Johns Hopkins Medical School, Baltimore.

Rabbits can be successfully infected with syphilis by the inoculation of surface wounds with virulent strains of Treponema pallidum. Old granulating wounds in these animals constitute a particularly favorable terrain for syphilis inoculation, the chancre developing relatively soon and attaining a greater size than the lesion occurring on the basis of a fresh wound. Coal tar dermatitis renders the skin susceptible to infection with Treponema pallidum.

The possible reasons for these phenomena are discussed and an hypothesis to account for them is advanced.

 Submitted on November 18, 1924


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