The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 40, 301-317, Copyright, 1924, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.



Michael Heidelberger Ph.D.1 and Oswald T. Avery M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research.

1. The method for the concentration and purification of the soluble specific substance of Pneumococcus has been improved.

2. Highly purified specific substance of Type II pneumococcus of polysaccharide nature is shown to be recovered essentially unchanged after precipitation by immune serum, by uranyl nitrate, by basic lead acetate, or by safranine.

3. Marked chemical differences are shown to exist between the specific substances of Type II and Type III pneumococcus, although both react as polysaccharides.

4. The weight of evidence is considered to be in favor of the view that the specific substances of Pneumococcus Types II and III are actually polysaccharide derivatives.

5. The immunological significance of the foregoing view is discussed.

 Submitted on April 16, 1924


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