The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 39, 457-471, Copyright, 1924, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : II. THE TOXIC EFFECT OF KILLED BACTERIA IN ADRENALECTOMIZED RATS.



W. J. M. Scott M.D.1

1 From the Laboratory of Surgical Research of Harvard Medical School, Boston.

1. The resistance of rats to bacterial intoxication is greatly decreased after double adrenalectomy.

2. This decreased resistance is dependent upon a functional insufficiency of the adrenal cortex.

3. A dose of killed streptococci or staphylococci can be obtained that is invariably fatal to adrenalectomized rats, before hypertrophy of cortical accessories, but never kills control rats.

 Submitted on October 10, 1923


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